Breast cancer incidence among BRCA-mutated ovarian cancer patients: systematic review and meta-analysis

Mutation in BRCA1 and BRCA2 increase breast cancer (BC) and ovarian cancer (OC) risk. Recommendation for BC surveillance in BRCA-mutated patients with OC are limited. Systematic review and meta-analysis investigated BC risk post-OC in BRCA-mutated women. A total of 2380 OC patients from 10 retrospective cohort studies were included. Among these patients, 181 (8%) developed BC post-OC, with similar rates observed for BRCA1 and BRCA2 mutated. In overall survival analysis, BRCA-mutated patients who developed BC after OC had significantly improved outcomes compared to those with OC only (HR 0.4657; p<0.001). The authors conclude that this meta-analysis underscores the need for tailored BC surveillance and evidence-based screening guidelines in BRCA-mutated OC survivors.