Associations of KRAS variant subtypes with recurrence and survival after surgery for intrahepatic cholangiocarcinoma

KRAS variants are associated with tumor progression; however, the prevalence of KRAS variant subtypes and their association with recurrence and survival after curative resection for intrahepatic cholangiocarcinoma are largely unknown. A study at Fudan University (Shanghai, China) charcterized the distribution of KRAS variant subtypes in a large cohort of ICC patients. The study showed that among patients undergoing curative resection for intrahepatic cholangiocarcinoma, presence of G12 KRAS variants but not non-G12 KRAS variants was associated with worse disease-free and overall survival. Patients with the G12V variant had the worst DFS and OS.