Association of radiation and procarbazine dose with risk of colorectal cancer among survivors of Hodgkin lymphoma

Hodgkin lymphoma (HL) survivors have higher rates of colorectal cancer when compared with the general population. A case control study among 5-year HL survivors at five centers in The Netherlands found a dose-response association between radiation therapy and colorectal cancer risk, and modification of this association by procarbazine. The authors conclude that these findings enable individualized colorectal cancer risk estimations, identification of high-risk survivors for subsequent screening, and optimization of treatment strategies.