Association of neighborhood-level household income with 21-gene recurrence score and survival among patients with ER-positive breast cancer

While low income has been associated with a higher incidence of triple-negative breast cancer, its association with 21-gene recurrence score (RS) among patients with ER-positive breast cancer remains unclear. Analysis of data in the National Cancer Database found that low household income (below the median of $ 50,353 per year) was independently associated with higher RS and significantly worse survival outcomes among those with RS below 26, but not 26 or higher.