Association of geographic origin with outcomes of Hispanic patients with non-small cell lung cancer in the United States

There are over 50 million self-identifying Hispanics in the United States. Analysis of a cohort of Hispanic patients with NSCLC for which region of origin was documented in the National Cancer Database (n=12,557) found that after adjustment for age, sex, histology, grade, insurance status, and facility type geographic origin was a significant predictor of advanced stage at diagnosis (p=0.015). Compared to Cubans, patients of Puerto Rican origin were less likely to present with advanced disease (OR 0.82; p=0.026). There was also a significant (log-rank p-value <0.001) differend in overall survival by geographic origin, even at early stages of diagnosis. Dominican patients had the highest 5-year OS rate (63.3%), followed by patients from South/Central America (59.7%), Puerto Rico (52.3%), Mexico (45.9%), and Cuba (43.8%).