Association of diet quality and risk of prostate cancer grade reclassification among men undergoing active surveillance

It is not clear whether diet may influence the risk of prostate cancer grade reclassification in men undergoing active surveillance. A prospective study among men in the Johns Hopkins Active Surveillance Program (Johns Hopkins University, Baltimore, MD) included men diagnosed with grade group (GG) 1 prostate cancer who completed a validated food frequency questionnaire before the start of active surveillance. In this cohort study of 886 men, after adjustment for baseline covariates, higher baseline Healthy Eating Index (HEI) and energy-adjusted HEI scores were associated with lower risk of grade reclassification to GG2 or greater and to GG3 or greater. The authors conclude that in men diagnosed with GG1 prostate cancer undergoing active surveillance, stricter adherence to American dietary guideline recommendations, indicated by higher HEI and energy-adjusted HEI scores, may be associated with reduced risk of grade reclassification, particularly to GG3 or greater disease, which mandates curative treatment.