Association of copy number variation signature and survival in patients with serous ovarian cancer

A genetic association study using the Cancer Genome Atlas Ovarian Cancer database assessed genome-wide survival assocations in patients with serous ovarian cancer (stages I-IV). A total of 13 genome regions, comprising 14 alterations, were identified as significantly risk associated. A composite CNV-based risk score identified three risk groups with median OS of 2.9 (95% CI 2.3-3.2), 4.1 (3.7-4.8), and 5.7 (4.7-7.4) years (p<0.001). The risk score had more discriminatory ability to prognosticate OS than the combination of age, clinical stage, grade and race.