Association of adherence to American Cancer Society guideline for survivors and mortality among men with nonmetastatic prostate cancer

The American Cancer Society Nutrition and Physical Activity Guideline for Cancer Survivors (ACS guideline) recommends avoiding obesity, engaging in regular physical activity, and following a healthy diet. In a cohort study of 4234 men with nonmetastatic prostate cancer, higher ACS guideline concordance after diagnosis (adherence score 6-8 versus 0-3) was associated with a 23% lower risk of all-cause mortality and a 25% lower risk of cardiovascular mortality; both results were statistically significant. Patients who improved their concordance after diagnosis experienced meaningful reductions in mortality risks. The authors conclude that these findings suggest that following the ACS guideline may reduce risk of mortality in men with nonmetastatic prostate cancer.