Analysis of dyslipidemia and cardiovascular disease among childhood cancer survivors in the St. Jude Lifetime Cohort

Analysis in the St. Jude Lifetime cohort evaluated the prevalence and associated cardiovascular risks of specific lipid abnormalities among childhood cancer survivors. Among survivors without a previous diagnosis of dyslipidemia, abnormal LDL-C was seen in 4%, abnormal non-HDL-C in 6%, abnormal HDL-C in 30%, and elevated triglycerides in 17%. Survivors had higher LDL-C and non-HDL-C and lower HDL-C than community controls. These abnormalities were associated with increased risks of myocardial infarction and cardiomyopathy.