Alcohol consumption and upper aerodigestive tract squamous cell carcinoma: pooled analysis of 28 prospective cohorts

Pooled analysis of 28 prospective cohorts within the Pooling Project of Prospective Studies of Diet and Cancer (DCPP) used individual-level data from 2,365,437 participants to estimate the association of alcohol consumption with upper aerodigestive tract (UADT) squamous cell carcinoma. Over a median follow-up of 15.5 years, 6903 UADT cancer cases were identified. Alcohol consumption was positively associated with UADT cancers risk, irrespective of smoking status or beverage type. The authors conclude that these findings support public health strategies to reduce alcohol consumption.