Active surveillance for low-risk prostate cancer: association of PSA velocity with clinical progression

A retrospective study among Veterans Health Administration patients undergoing active surveillance for low-risk prostate cancer found that PSA velocity is significantly associated with grade progression, but at lower values for African American patients compared with non-Hispanic White patients. These data suggest that serial PSA measures may potentially substitute for multiple prostate biopsies and that African American patients may merit increased frequency of PSA testing.